Creature Spawning

Monsters/creatures/animals will all generally respawn unless they are part of a quest.

In addition to static monster spawns, there is also a chance for random spawns in some areas such as the crypts and mines. You will on occasion notice that a creature will spawn around you if you are not already being attacked. So becareful wandering in areas. What spawns during random encounters will also change as you level up.

Item Spawning

By default, container spawns as well as breakable barrels, crates, etc… will not respawn in single player mode. This can be changed in the world difficulty if you would like them to. The only exception to this is doors, which should generally respawn a short time after being broken down.

There are also item spawns that occur in areas such as mines and crypts as you explore. The most common resource to spawn is reagents based on the environment. For example, while wandering the mines, you may notice Brimstone and ash that can be picked up from the ground. These spawns are generated as you explore an area.